Abstract—Recent developments in various applications have led to the rapid growth in demand for bandwidth by users. It has enhanced the need for solutions that provide abundant bandwidth at a reduced cost. Radio-over-fibre (RoF) enables simpler and more efficient transmission of communication signals compared to traditional radio frequency (RF) methods. Wavelength-division multiplexing (WDM) enhances optical communication by enabling the transmission of optical signals at multiple wavelengths thereby increasing the bandwidth capacity of the transmission process. Hybrid RoF/WDM systems have also found applications in recent communication methods. Despite their advantages, RoF-WDM systems suffer from significant power loss and dispersion over long distances, optical amplifiers are therefore usually used to improve signal reception. In this paper, the performance of an Erbium-doped fiber amplifier (EDFA), a semiconductor optical amplifier (SOA), and a Raman amplifier is investigated over a long-distance RoF-WDM communication system. The EDFA exhibited improved received power at all destination lengths, with the best being 19.2128 dB at the 10 km destination length. The SOA had the best Q-factor and BER performance at the 10 km and 25 km destination lengths. Specifically, SOA produced BER of 1.2166610-7 and 5.6260310-8 and a Q-factor of 5.15645 and 5.2966 at 10 km and 25 km respectively. At the 60 km destination length, the Raman amplifier exhibited the best Q-factor (4.6517) and BER (1.2779710-6). In conclusion, for transmission using RoF-WDM systems over long distances, EDFA and Raman amplifiers are most suitable.